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Conditions marked by altered redox status, such as mutations in antioxidant enzymes or mitochondrial mutations, should also be considered potential risk factors for the disease
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10.3390/nu11112705 Nutrients 12 ChaudhuriD.GhateN.PanjaS.DasA.MandalN
4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage
